Forskolin Review

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ForskolinForskolin is a chemical substance that is extracted from the roots of the plant Plectranthus barbatus (Coleus forskohlii). Also known as colforsin or makandi orpashanabhedi, the plant has recently been publicly recognized for its purported weight loss benefits. Forskolin has also been used for centuries to treat respiratory disorders such as asthma, as well as heart disorders such as high blood pressure and angina (chest pain). Forskolin has also been used, intravenously, by herbal health providers to treat heart failure. In today’s medicine, Forskolin is commonly used to raise levels of cyclic adenosine monophosphate (cAMP) in the research and study of cell physiology.

When taken orally, Forskolin is helps in the treatment of allergies, skin conditions such as eczema and psoriasis, painful menstrual periods, obesity, irritable bowel syndrome (IBS), bladder infections, urinary tract infections (UTI), advanced cancer, insomnia, blood clots, sex problems in men, and convulsions. Forskolin can also be administered as an eye-drop to treat eye complications such as glaucoma. To date, two clinical studies, sponsored by Sabinsa Corporation – an herbal supplement manufacturer, have been carried out to examine if Forskolin can aid weight loss.

Forskolin Details

For weight loss

Forskolin has been formulated to offer the best possible chance to get rid of any hard-to-burn belly fat or burn off the fatty calves. When coupled with healthy living and regular exercise, Forskolin as a dietary supplement helps users lose the extra baggage. Within the body cells is a fat burning adenylate cyclase which, in the presence of Forskolin extract, is strongly activated via the chemical precursor adenosine monophosphate (AMP) which then triggers the body cells to burn stored fat for energy through a thermogenic action which involves conversion of lipids to heat and energy. In addition, Forskolin plays a very crucial role in blocking the storage of fat from the foods people do eat. When taken before a meal, the supplement primes the body to better absorb and process the nutrients and convert them to energy instead of having them diverted into energy storage.

For Asthma

Results of medical research and studies have convincingly proved that for the treatment of asthma due to its ability to act as a bronchodilator. The results suggest that Forskolin has a dose-dependent relaxant effect on resting tone and leukotriene C4, leukotriene D4, and carbachol-induced contraction f tracheal smooth muscles. According to the research findings, Forskolin is very effective in relaxing and smoothing the muscles of the respiratory tract and in decreasing the airway constriction that is responsible for breathing difficulty in asthmatic patients.

For Depression

Depression is caused by imbalance of neurotransmitters in the brain – most commonly either the dopaminergic (stimulatory) or serotonergic (inhibitory). Forskolin increases cAMP and inhibits phosphodiesterase, thereby raising the catecholamine level which in turn enhances the functions of neurotransmitters, hence eliminating depression.

For Glaucoma

Forskolin is a lipid-soluble compound that can penetrate the cell membranes and stimulate the production of enzyme adrenaline cyclase. This in turn stimulates the body’s ciliary epithelium to activate the cAMP which reduces the body’s intraocular pressure (IOP) by decreasing the aqueous humor inflow and preventing the optic nerve damage before treatment by an optician begins.

For Hypertension and other cardiovascular disorders

One of the consequences of increased level of cAMP in the body is relaxed arteries and intensified contractility of the heart, and, therefore, lowered blood pressure. Forskolin is also used to treat angina pectoris and congestive heart failure. It also hastens recovery from strokes by boosting the blood supply to the brain.

For Psoriasis and Eczema

Psoriasis is a condition characterized by a situation where body cells divide about 1000 faster than normal. It is caused by a decrease in the level of cAMP relative to the second messenger, cGMP – cyclic guanine monophosphate, thereby creating an imbalance that leads to a tremendous increase in cell division. Forskolin helps to treat psoriasis by increasing the cAMP level hence normalizing the cAMP and cGMP ratio.

For Cancer and Metastasis

Clinical research findings have proved that Forskolin has an inhibitory effect on the migration of tumor in mice. This shows that, theoretically, Forskolin can inhibit the growth of colon cancer cell and platelet aggregation in humans. In response to this inhibiting property, the growth of metastatic tumors can be equally prevented.

For Immune System

Forskolin exhibits potent immune system enhancement by activating lymphocytes and macrophages, hence enhancing the body’s defense mechanism against disease-causing microorganisms.

For Erectile Dysfunction and Vasculogenic Impotence

One study carried out in 1997 found out that Forskolin has a role in the management of vasculogenic impotence, when injected into the corpus cavernosum of the penis. The two areas of corpus cavernosa lie along the shaft and are filled with much blood during erection. Forskolin acts in synergism with prostaglandin E1 to induce smooth muscle relaxation. When coupled with vasoactive agents, the extract showed a preliminary efficacy and safety in victims of vasculogenic impotence that is resistant to standard 3-agent pharmacotherapy.

For Hypothyroidism

Forskolin has demonstrated to promote the production and release of thyroid hormone. When thyroid hormone is brought to its optimum level, any deficiency that may trigger hypothyroidism is completely vetoed.

Advantages

  • It is a natural herb, meaning it is free of harmful chemical ingredients found in most prescribed or OTC drugs
  • It has been used for centuries and clinically proven to be effective
  • It is a multi-purpose medicinal herb that treats a wide range of illnesses and health complications
  • It has no clear ties to any serious side effects and can be taken along other caffeine’s

Disadvantages

  • It is recommended for pregnant women
  • It may cause irritation of the upper respiratory tract, and restlessness when inhaled.
Conclusion

Generally, Forskolin is a very effective drug in treating a wide array of diseases and the dream answer to every dieter. However, it is recommended that you consult your doctor or medical provider about all medications you’re taking prior to beginning your treatment with Forskolin. This is necessary because the extract may not work in conjunction with other prescribed medications such as prescription blood-thinners, a combination that may result in an increased risk of developing bleeding complications.

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